【摘要】 目的评价纳米炭标识前哨淋巴结(SLN)对结肠直肠癌腹腔淋巴结转移状况判断的价值。方法50例初次接受手术且术前未接受放化疗的结肠直肠癌患者,以纳米炭淋巴示踪剂进行术中染料定位,黑染的第1～4个淋巴结定义为SLN并缝线标记,随后行标准的结肠直肠癌根治术,标本术后送病理检查。结果50例患者中47例找到SLN,SLN检出成功率为94%;共找到SLN104枚,平均每例标本检出SLN2.2枚(104枚/47例)。准确率为95.7%(45例/47例);特异性为93.1%(27例/29例);假阴性率为10%(2例/20例);阴性预测值为93.1%(27例/29例)。结论SLN检测判断结肠直肠癌区域淋巴结转移状况简单且准确,可作为结肠直肠癌患者手术治疗的参考。更多还原

【Abstract】 Objective To evaluate the value of sentinel lymph nodes(SLN)in prediction of the celiac lymph nodes status.Methods Carbon nanoparticles were injected into the periphery of the tumor in 50 patients before/during the operation.After 5 minutes,the first black-dyed 1 to 4 lymph nodes were sewed to define as SLN.Then the curative resection were carried out and the samples were examined by pathologist after operation.Results SLNs were found in 47 patients,104 SLNs were identifi ed,the mean number was 2.2.The detection rate of SLN was 94%(47/50);the accuracy was 95.7%(45/47);the specifi city was 93.1%(27/29),the false negative was 10%(2/20)and the negative predictive value was 93.1%(27/29).Conclusion SLN can be easily detected and can precisely predict the celiac lymph nodes status in colorectal carcinoma.The technique of sentinel node biopsy(SNP)may be a part of routine therapeutic tool in management for colon and upper rectal cancer.更多还原