【摘要】 目的:探讨男性严重少精子症和无精子症与染色体异常的关系。方法:对364例严重少精子症和无精子症患者进行外周血淋巴细胞培养,G显带染色体核型分析。结果:严重少精子症和无精子症异常染色体检出率分别为6.29%(9/143)、11.76%(26/221)。严重少精子症以染色体易位为主77.78%(7/9),无精子症以染色体数目畸变占大多数88.46%(23/26)。结论:染色体异常是导致严重少精子症和无精子症的重要原因之一,在卵胞浆内单精子显微注射治疗前进行染色体核型分析是必要的。更多还原

【Abstract】 Objective:To study the relation between severe oligospermia, azoospermia and abnormal chromosome karyotypes. Methods: The periphery blood lymphocyte was cultured and the G-banding chromosome was analyzed on 394 male patients with the severe oligospermia and azoospermia.Results: The incidence of abnormal chromosome karyotype was 6.29% or 9/143 in patients with severe oligospermia by the G-banding, which account for 77.78% or 7/9 in chromosome translocation. The incidence of abnormal chromosome karyotype was 11.76% or 26/221 in patients with azoospermia by the G-banding, which account for 88.46% or 23/26 in numerical chromosome aberration .Conclusions: Chromosomal abnormalities may dramatically cause severe oligospermia and azoospermia. It is very necessary to take the chromosome karyotype examination on patients with severe oligospermia and azoospermia before they accept the treatment of intracytoplasmic sperm injection.更多还原