【摘要】 目的研究聚乙二醇干扰素α-2a治疗慢性丙型肝炎的疗效。方法设观察组(接受聚乙二醇干扰素α-2a治疗,联合利巴韦林口服)36例,对照组(接受普通干扰素α-2a治疗,联合利巴韦林口服)32例,在治疗前、治疗中、48周治疗结束及随访24周后,分别检测丙型肝炎病毒(HCV)RNA、血清丙氨酸转氨酶(ALT),比较两组治疗效果。结果48周治疗结束时,观察组的病毒学应答率和生物化学应答率均为88.89%,对照组分别为75.00%、81.25%,两组治疗结束时疗效无明显差异(均P>0.05)。观察组早期病毒学应答率、持续应答率分别为47.22%、80.55%,明显高于对照组的12.50%、31.25%(分别χ2=9.57,P<0.05;χ2=16.84,P<0.05);观察组复发率为8.33%,显著低于对照组的43.75%(χ2=11.33,P<0.05)。结论聚乙二醇干扰素α-2a治疗慢性丙型肝炎的疗效优于普通干扰素α-2a。更多还原

【Abstract】 Objective To evaluate the effect of Pegylated interferon(PEG-IFN)α-2a on treating chronic hepatitis C.Methods Sixty-eight chronic hepatitis C cases were divided into observation and control group,36 cases in observation group received PEG-IFN α-2a plus ribavirin,32 cases in control group received interferon plus ribavirin,HCV RNA and serum alanine transaminase(ALT)were detected in two groups before treatment,during treatment,at the end of 48-week treatment and 24-week of follow-up,the treatment effect was compared between two groups.Results At the end of 48-week treatment,virological response rate and biochemical response rate were both 88.89%in observation group,and it was 75.00% and 81.25% respectively in control group,there were no significant difference in the treatment effect at the end of treatment between two groups(both P> 0.05).The early virological response rate and sustained virological response rate was 47.22% and 80.55% respectively in observation group,which was significantly higher than 12.50% and 31.25% respectively in control group(χ2=9.57,P<0.05;χ2=16.84,P<0.05;respectively);The relapse rate was 8.33% in observation group,which was significantly lower than 43.75% in control group(χ2=11.33,P<0.05).Conclusion The effect of PEG-IFN α-2a on treating chronic hepatitis C is superior to IFN α-2a.更多还原