【摘要】 目的:研究夜来香正丁醇提取物的抗心律失常作用。方法:夜来香正丁醇提取物腹腔注射用于预防由氯仿引起的小鼠室颤、由氯化钙引起的大鼠室颤、由乌头碱引起的大鼠心律失常和肾上腺素引起的心律失常。结果:夜来香正丁醇提取物能有效地抑制氯仿引起的小鼠室颤;能明显地预防由氯化钙引起的大鼠室颤;能明显地抑制由乌头碱引起的大鼠心律失常。夜来香正丁醇提取物的抗心律失常作用与抑制Na+和Ca2+内流有关,且成剂量依赖性。夜来香正丁醇提取物能拮抗由肾上腺素引起的家兔心律失常。结论:夜来香正丁醇提取物具有明显的抗心律失常作用,其作用可能与阻断钠通道、钙通道和β受体有关。更多还原

【Abstract】 Objective:To study the effect of Cestrum Nocturnum n-Butyl Alcohol Extract on Antiarrhythmia.Methods: The conventional antiarrhythmia methods were used.Results: It has been found that Cestrum Nocturnum n-Butyl Alcohol Extract is remarkedly effective in preventing ventricular fibrillation induced by chloroform in mice and arrhythmia induced by aconitine in rats.The arrhythmia induced by adrenalin in rabbits was antagonized by Cestrum Nocturnum n-Butyl Alcohol Extract and it can obviously inhibit the action potential amplitude of isolated sciatic nerves in toads.And it can also prevent ventricular fibrillation induced by calcium chloride in rats,it can obviously reduce the death rate of rats.And its anti-arrhythmic effect was dose-dependent.Conclusion: Cestrum Nocturnum n-Butyl Alcohol Extract has obviously a protective effect on drugs induced arrhythmia,which may be related to its inhibition of Na+ or Ca2+influx and its blocking β-adrenergic receptor.更多还原