【摘要】 目的研究ERK2在食管鳞状细胞癌组织中的表达及临床意义。方法应用免疫组化S-P法检测食管正常黏膜、癌旁组织及食管癌组织中ERK2表达状况。结果食管正常黏膜、癌旁组织及食管癌组织中ERK2表达率分别为20.0%(4/20)、45.7%(16/35)及86.2%(81/94),食管癌组织中ERK2表达率明显高于正常黏膜及癌旁组织组(P<0.05)。正常黏膜组和癌旁组织组ERK2表达率无明显差异(P>0.05),食管癌组织中ERK2表达与患者年龄、性别、肿瘤浸润深度、组织分化、淋巴结转移、临床分期及其它临床病理因素无关(P>0.05)。结论ERK2过表达在食管癌发生中起重要作用,单独检测ERK表达可能无助于判断患者的预后。更多还原

【Abstract】 Objective To study the expression and clinical significance of ERK2 in esophageal squamous cell carcinoma(SCC).Methods Using immunohistochemistry S-P method, the expression of ERK2 was examined in normal esophageal mucosa, pericancerous tissues and esophageal cancer tissues.Results The expression rates of ERK2 were 20.0% (4/20), 45.7%(16/35)and 86.2% (81/94)in normal esophageal mucosa, pericancerous tissues and esophageal cancer tissues, respectively. The expression rate of ERK2 in esophageal cancer tissues was significantly higher than that in normal esophageal mucosa and pericancerous tissues(P<0.05).There was no difference between normal esophageal mucosa and pericancerous tissues in ERK2, expression(P>0.05). No significant correlation was observed between ERK2 expression and patients’ age and sex,the depth of infiltration, histological differentiation, lymph node metastasis,tumor stages and other clinicopathological manifestations (P>0.05).Conclusion The data suggest that overexpression of ERK2 plays a critical role in the esophageal carcinogenesis. The examination of ERK2 only may not assist in evaluating the prognosis of esophageal squamous cell carcinoma.更多还原