【摘要】 目的探讨厄贝沙坦对原发性高血压患者左心室肥厚(LVH)及心率变异性(HRV)的影响。方法65例原发性高血压患者,每日清晨7时口服厄贝沙坦,治疗前及治疗6个月后分别测定患者LVH及HRV。结果治疗后的左室后壁舒张末期厚度(LVPWT)、左室舒张末期内径(LVDd)、室间隔舒张末期厚度(IVST)、左室重量指数(LVMI)均比治疗前明显减少(P<0.01);与治疗前相比,相邻正常RR间期标准差(SDNN)、相邻正常RR间期差值的方差(RMSSD)、相邻正常RR间期差值大于50 ms的窦性心律占心搏总数的百分比(PNN50)、高频功率(HF)明显增加(P<0.01),而低频功率(LF)及LF/HF则明显降低(P<0.05或0.01)。结论厄贝沙坦对原发性高血压患者的LVH有显著的改善作用,对HRV有显著的扭转作用。更多还原

【Abstract】 Objective To study the effect of irbesartan on left ventricular hypertrophy(LVH)and heart rate variability(HRV)in patients with essential hypertension(EH).Methods Sixty-five EH patients received oral irbesartan once daily.LVH and HRV were determined before and 6 months after irbesartan treatment.Results Compared with before irbesartan treatment,standard deviation of normal to normal intervals(SDNN),rate mean square of the differences of successive RR intervals(RMSSD),percentage of RR intervals differing >50 ms(PNN50),and high frequency(HF)increased,while left ventricular posterior wall thickness(LVPWT), left ventricular diastolic dimension(LVDD),interventricular septal thickness (IVST),left ventricular mass index(LVMI),low frequency(LF)and LF/HF decreased after treatment(P<0.05 or 0.01).Conclusion Irbesartan can improve LVH and HRV in EH patients.更多还原