【摘要】 目的评价汇集滤白细胞血小板的质量和临床效果。方法用白膜层法制备手工浓缩血小板,再以60~70mL/min的速度对汇集血小板进行白细胞过滤。30袋汇集滤白细胞血小板过滤前后分别进行血小板含量、白细胞残留量检测和细菌培养,并观察87例出血患者(血液病16例、非血液病71例)输注后24 h疗效。结果30袋汇集滤白细胞血小板过滤前后血小板含量差异无统计学意义(P>0.05),白细胞残留量差异有统计学意义(P<0.01),细菌培养均为阴性。非血液病出血患者输注汇集滤白细胞血小板的有效率是85.9%,而血液病患者输注有效率是75.0%。结论汇集滤白细胞血小板质量指标均达到单采血小板国家质量标准,临床应用效果良好。更多还原

【Abstract】 Objective To evaluate the quality and clinical effectiveness of leukocyte-filtrated platelet concentrate.Methods The platelet concentrate was prepared manually by buffy coat,and then filtrated at the speed of 70 mL/min for removal of leukocyte.Thirty bags of platelet concentrates were detected by platelet and WBC count and bacterial culture before and after leukocyte filtration.The 24-h clinical efficacy in 87 patients with hemorrhagic disease(hematologic diseases,16;non-hematologic diseases,71)was observed after infusion of leukocyte-filtrated platelet concentrate.Results Platelet count remained intact(P>0.05)and bacterial culture was negative,but WBC count decreased obviously(P<0.01)after leukocyte filtration in 30 bags of platelet concentrates.The effective rates were 85.9% and 75.0% in non-hematologic and hematologic patients,respectively.Conclusion The quality of the leukocyte-filtrated platelet concentrate meets the state criterion for single-sampling platelet,and its clinical efficacy is satisfactory.更多还原