【摘要】 探讨了光激发纳米TiO2对胃癌SGC-7901细胞的杀伤作用,考察了在不同纳米TiO2浓度及不同光照时间下纳米TiO2的抑瘤效果,并探讨了抑瘤机制.结果表明,光激发纳米TiO2对胃癌SGC-7901细胞具有明显的抑制作用,其过程类似一级反应的动力学规律;当纳米TiO2浓度为300μg/mL时,对胃癌SGC-7901细胞表现出较强的杀伤效果,其主要表现形式有两种,即细胞坏死和细胞凋亡,是由光激发条件下,纳米TiO2表面产生的活性氧组分对肿瘤细胞的有效杀伤所致.更多还原

【Abstract】 Damaging effects of photoexcited TiO2 nanoparticles on gastric cancer SGC-7901 cells were investigated.The influences of nanosized TiO2 content,and irradiation time on cancer inhibition were systematically studied,and the inhibition mechanism was primarily discussed.The results demonstrate that photoexcited TiO2 nanoparticles exhibit good inhibition effects on gastric cancer SGC-7901 cells,and this process follows appro-ximately first-order reaction rule.While the concentration of TiO2 nanoparticles is about 300 μg/mL,the damaging effects are rather remarkable.In addition,the exhibition forms of gastric cancer SGC-7901 cells are apoptosis and necrosis in killing experiments.Taken together,damaging effects of photoexcited TiO2 nanoparticles on gastric cancer SGC-7901 cells might be attributed to the reactive oxygen species formed on the TiO2 nanoparticles surface.更多还原