【摘要】 本文报道了一种利用多组分反应合成α-氰基噻吩的新方法.在碱存在条件下,β-二羰基化合物、二硫化碳和溴乙腈经过连续的多步反应,"一锅"合成多官能团化的α-氰基噻吩.该方法简洁,条件温和,产率高.更多还原

【Abstract】 A convenient one-pot synthesis of highly functionalized α-cyanothiophene derivatives(4) by three-component reactions was developed. In the presence of K2CO3,1,3-dicarbonyl compounds 1 reacted with CS2(2) and bromoacetonitrile(3) resulted in the formation of functionalized α-cyanothiophenes(4) in high yields. The simplicity of execution,mild conditions,ready availability of substrates and high yields,make this synthetic strategy considerably attractive for academic research and practical applications.更多还原