【摘要】 目的探讨转化生长因子(TGF)β1-509C/T基因多态性与变应性鼻炎的关系。方法运用多聚酶链反应技术检测63例变应性鼻炎及110例正常人转化生长因子TGFβ1-509C/T基因多态性。结果变应性鼻炎组转化生长因子TGFβ1-509C/C、C/T、T/T表型频率分别为0.0953、0.3809、0.5238;对照组分别为0.1545、0.40、0.4455;变应性鼻炎组TGFβ1-509C、TGFβ1-509T基因频率分别为0.2857、0.7143,对照组分别为0.3545、0.6455,TGFβ1-509C/T各种基因型频率在患者组与正常对照组之间的差异无统计学意义(P>0.05)。结论TGFβ1-509C/T基因多态性与变应性鼻炎无明显相关。更多还原

【Abstract】 Objective To investigate the relationship of TGFβ1-509C/T polymorphism and allergic rhinitis.Methods The polymorphism of TGFβ1-509C/T gene was screened by PCR-RELP in 63 patients with allergic rhinitis(AR group) and 110 normal people.Results The gene frequency of TGFβ1-509C/T in AR group was as follow:TGFβ1-509 C/C,C/T and T/T genotype frequency was 0.0953,0.3809 and 0.5238,respectively,the gene frequency in control group was 0.1545,0.40 and 0.4455;TGFβ1-509C,TGFβ1-509T gene frequency was 0.2857 and 0.7143 respectively,in control group,TGFβ1-509C,TGFβ1-509T genefrequency was 0.3545,and 0.6455 respectively.There were no significant differences in the frequencies of TGFβ1-509C/T gene between the patient and control group(P>0.05).Conclusion No evident association was found between TGFβ1-509C/T polymorphism and allergic rhinitis.更多还原