【摘要】 目的探讨HBV感染者血清IP-10和RANTES水平及其临床意义。方法采用ELISA定量检测正常人、自限性HBV感染者、慢性HBV携带者和慢性乙型肝炎患者血清IP-10和RANTES水平。结果与正常人比,自限性HBV感染者、慢性HBV携带者和慢性乙型肝炎患者血清IP-10(P=0.002,P=0.002,P=0.01)和RANTES(P=0.01,P=0.02,P<0.001)表达均明显上调;自限性HBV感染者、慢性HBV携带者和慢性乙型肝炎患者之间血清IP-10水平无显著性差异(P>0.05),但自限性HBV感染者血清RANTES水平较其他两组明显升高(P=0.005,P=0.03);慢性乙型肝炎患者血清IP-10(P=0.001)和RANTES(P=0.02)水平均明显高于慢性HBV携带者;HBeAg阴性和阳性者之间两指标无显著性差异(P=0.08,P=0.42);HBV DNA阳性者血清IP-10(P=0.016)和RANTES(P=0.02)水平均明显高于HBV DNA阴性者。结论IP-10和RANTES的趋化作用广泛参与了机体对HBV免疫应答的各个阶段,并在肝脏组织的炎性损伤中发挥了作用。更多还原

【Abstract】 Objective To investigate the serum chemokine IFN-γ-inducible protein-10(IP-10) and RANTES levels in individuals with HBV infection.Methods The serum IP-10 and RANTES levels was detected by enzyme linked immunosorbent assay.Results Self-limited HBV infected individuals,chronic HBV carriers and chronic hepatitis B patients showed elevated serum IP-10(P=0.002,P=0.002,P=0.01,respectively) and RANTES(P=0.01,P=0.02,P<0.001,respectively) levels as compared with normal persons;self-limited HBV infected persons showed higher serum RANTES(P=0.005,P=0.03,respectively) levels than those in chronic HBV carriers and hepatitis B patients,but not of IP-10(P>0.05,P>0.05);the HBV infected patients had higher serum IP-10(P=0.001) and RANTES(P=0.02) than in HBV carriers;no difference of them were found between persons with negative and positive serum HBeAg;the patients with positive serum HBV DNA had higher serum IP-10(P=0.016) and RANTES(P=0.02) levels than in with negative HBV DNA.Conclusion It is possible that IP-10 and RANTES play a cretical role in each stage of host immune response against HBV,which might be responsible for the liver damage indirectly.更多还原