【摘要】 目的观察桃红四物汤对激素性股骨头缺血性坏死大鼠转化生长因子β1(TGF-β1)mRNA转录的影响,探讨其防治激素性股骨头坏死的作用机制。方法模型组每周2次腹腔注射醋酸泼尼松龙24.5mg/kg,经6周诱导出早期激素性股骨头缺血坏死的模型,随机分为治疗组16只和对照组16只,分别灌服桃红四物汤和生理盐水,在灌胃后第6、8周,检测股骨头局部TGF-β1 mRNA的转录水平。结果治疗组股骨头局部TGF-β1 mRNA的转录水平呈逐渐增强的趋势,而对照组股骨头局部TGF-β1 mRNA的转录水平则呈逐渐减弱的趋势,2组差异显著。结论桃红四物汤可促进激素性股骨头缺血坏死模鼠股骨头局部TGF-β1 mRNA的转录水平,促进坏死股骨头的修复。更多还原

【Abstract】 Objective To investigate the effect of Taohong Siwu decoction on transcription of transforming growth factor-β1(TGF-β1) mRNA of hormonal avascular necrosis of femoral head(HANFH) in rats. Methods The rats were injected abdominally with econopred 24.5 mg /kg for twice per week,and the early models of HANFH were successfully induced after six weeks. 32 rats were divided randomly into two groups,the treatment group(n=16) were administrated with Taohong Siwu decoction,and the control group(n=16) with physiological saline. The transcription level of TGF-β1 mRNA in femoral head was detected at 6th and 8th week after administration. Results The transcription level of TGF-β1 mRNA increased gradually in treatment group and decreased gradually in control group,there were statistical significance. Conclusion Taohong Siwu decoction can promote the transcription of TGF-β1 mRNA of HANFH and repair femoral head necrosis.更多还原