【摘要】 利用聚苯乙烯-丙烯酸(PSA)共聚物胶粒为模板,采用控制沉降和原位聚合的方法首先合成PSA@F e3O4/聚砒咯(PPy)复合核壳粒子;将去核后得到的F e3O4/PPy空心胶囊进一步热解炭化,制备了单分散F e3O4/C arbon空心胶囊.样品物相及结构经X射线衍射仪(XRD)、透射电子显微镜(TEM)和扫描电子显微镜(SEM)表征.超导量子干涉仪(SQU ID)测定结果显示,碳胶囊样品呈超顺磁性.N2气吸附测试结果显示磁性碳胶囊的比表面积BET为98 m2/g.以F e3O4/C arbon磁性空心胶囊对抗癌药物阿霉素进行负载后,体外模拟释放实验结果显示胶囊具有良好的药物缓释性能.更多还原

【Abstract】 A versatile approach is reported for fabrication of ferromagnetic carbon hollow capsules.PSA@Fe3O4/polypyrrole(PPy) core-shell latex was firstly fabricated then transformed to Fe3O4/PPy hollow capsule after removed core.Carbon hollow capsules were obtained via carbonization-reduction process from Fe3O4/PPy capsules heated at 550oC.Their microstructures were observed by a high resolution transmission electron microscope(HRTEM) and the magnetism was characterized with a superconducting quantum interference device(SQUID) magnetometer.The hollow and porous characters made these sub-meter size ferromagnetic carbon hollow capsules becoming hopeful candidates as target drug carriers.Doxorubicin,a typical antineoplastic drug,was introduced into the capsules.A novel sustained drug release behavior of the loading capsules was discovered via performing a release test in the phosphate buffer solution(PBS,pH=7.4) at 37℃.更多还原