【摘要】 利用线性溶剂-能量关系模型(LSER)对分别以氨丙基硅胶(APS)和硅胶(SiO2)为基质的两种纤维素三(3,5-二甲基苯基氨基甲酸酯)(CDMPC)手性固定相(CSP)存在的作用力进行研究。利用33种分析物的LSER描述符号及分析物在固定相上的保留时间进行多元线性回归,通过对回归所得到的系统参数的分析来评价固定相存在的作用力。分析表明:两种固定相在正相条件下存在较弱的π-π作用力,较强的偶极-偶极作用力。而氢键作用力的大小受到基质的影响,以APS为基质的固定相给电子能力较强;而以SiO2为基质的固定相给质子能力较强。更多还原

【Abstract】 Linear solvation energy relationships(LSER)were used to evaluate the interactions exited on cellulose tris(3,5-dimethylphenylcarbamate)(CDMPC)-chiral stationary phase(CSP)and the effect of the support on the chiral separation.The 33 solutes descriptors and their retention factors were used to the multiple linear regressions analysis and statistical calculations.And the interaction existed in the chiral stationary phases was evaluated by the system parameters obtained by the multiple linear regression analysis.There are weaker π-π interactions and stronger dipole-or induced dipole-type interactions on the chiral stationary phases in normal phase.And the H-bond existed in the chiral stationary phase is affected by the support.CSP with aminopropy silica gel(APS)support has the stronger ability of H-bond donor,and CSP with SiO2 support has the stronger ability of H-bond acceptor.更多还原