【摘要】 目的:探讨CT引导下125I粒子治疗恶性肿瘤的临床应用价值。方法:搜集本院48例恶性肿瘤患者资料(男35例,女13例,年龄37~82岁),其中肺癌20例,肝癌4例,胰腺癌4例,肝、肺、肾、脊柱、骨骼、软组织及颈胸腹部淋巴结等部位转移性肿瘤共20例。全部患者经过放射粒子植入计划系统(TPS)计划,CT引导下植入125I粒子对肿瘤进行治疗,观察其疗效及相关并发症。结果:全部患者125I粒子均植入成功,其中43例患者追踪复查1~13个月,疗效评价:完全缓解(CR)10例,部分缓解(PR)21例,无变化(NC)5例,进展(PD)7例,临床总有效率(CR+PR)为72%。125I粒子植入过程中出现气胸5例,针道渗血4例,咯血3例,肝包膜下出血1例,粒子游走2例,无1例严重并发症。结论:CT导向下125I粒子植入治疗多种恶性肿瘤微创安全,疗效肯定。更多还原

【Abstract】 Objective:To study the clinical application of 125I implantation to treat malignant tumors under CT gui-dance.Methods:Of 48 patients(including 35 males and 13 females) with age ranging from 37 to 8 years old,there were 20 cases of lung cancer,4 cases of liver cancer,4 cases of pancreatic,and 20 cases of metastatic cancers at other parts of their bodies,such as liver,lung,kidney,spine,bone,soft tissue and lymph nodes of neck,chest and abdomen.All patients received the treatment plan system(TPS),and implanted 125I radioactive particles to treat the tumors.The effectiveness and relevant complications after the treatment were observed.Results:All patients were successfully implanted 125I radioactive particles,and 43 patients were traced and reexamined for 1 to 13 months after the operation.Total response rate was 72%,of which complete response was obtained in 10 cases,partial response in 21 cases,no change in 5 cases,and progressive disease in 7 cases respectively.During the 125I implantation,5 patients got pneumothorax,4 got pulmonary exudation,3 got hemoptysis,1 got liver subcapsular hemorrhage and 2 got particle migration.None of the patients got any serious complication.Conclusion:125I implantation under CT guidance is minimally invasive and safe for treating some malignant tumors,and the effect is affirmative.更多还原