【摘要】 目的:探讨了2型糖尿病(DM2)肾病患者血清瘦素(leptin)水平与红细胞膜Na+K+-ATP酶和Ca2+Mg2+-ATP酶活性改变参与DM2肾病发生的可能机制。方法:应用放射免疫分析和Reilni制膜法测定了40例DM2无肾病和32例DM2肾病患者血清leptin水平和红细胞膜Na+K+-ATP酶和Ca+2Mg+2-ATP酶含量,并与35名正常健康人作比较。结果:DM2无肾病组和肾病组血清leptin水平非常显著地高于正常人组(P<0.01)和红细胞膜Na+K+-ATP酶和Ca2+Mg2+-ATP酶水平显著地低于正常人组(P<0.01)。DM2肾病组与无肾病组亦有显著性差异(P<0.05)。结论:DM2的发生、发展与血清leptin水平和红细胞膜Na+K+-ATP酶和Ca2+Mg2+-ATP酶的活性有密切的关系。更多还原

【Abstract】 Objective To study the possible mechanism of dovelopment of nephrosis affected by changes of serum leptin levels and alteration of activities of Na+K+-ATPase and Ca2+Mg2+-ATPase of erythrocyte membrane in patients with type 2 diabetes(DM2).Methods Serum leptin levels(with RIA) and erythrocyte membrane Na+K+-ATPase and Ca2+Mg2+-ATPase activitities(with Reinila method) were determined in 40 DM2 patients without nephropathy,32 DM2 patients with nephropathy and 35 controls.Results Serum leptin levels were significantly higher in the diabetics as a whole than those in controls(P<0.01),while the RBC Na+K+-ATPase and Ca2+Mg2+-ATPase activities were significantly lower(P<0.01).Among the diabetic patients,the serum leptin levels in patients without nephrosis(P<0.05),but the RBC membrance ATPase activities were significantly lower(P<0.05).Conclusion Development of type 2 diabetes nephrosis might be correlated with the high serum leptin level and decreased ATPase activities of erythrocite membrane.更多还原