【摘要】 目的:探讨抑制素B(inhibin,INH-B)水平在多囊卵巢综合征(PCOS)患者血清中的变化及其与体重指数(BMI)的关系。方法:筛选PCOS患者40例,根据体重指数(BMI)分为肥胖组和非肥胖组并检测血清中的抑制素B(INH-B)、胰岛素生长因子-I(IGF-I)、空腹胰岛素(In)、瘦素(leptin)、黄体生成素(LH)、卵泡刺激素(FSH)、人体催乳素(PRL)、雌二醇(E2)和睾酮(T),另取40例排卵正常、无怀孕妇女做对照分析。结果:PCOS患者肥胖组leptin、In、LH、T水平明显高于非肥胖组,INH-B、IGF水平则明显低于非肥胖组,差异有统计学意义(P<0.05);且肥胖组的LH与INH-B呈负相关(r=-0.735,P<0.05),非肥胖组的LH与INH-B无明显相关性。非肥胖组INH-B、IGF、LH、T水平明显高于对照组,差异有统计学意义(P<0.05)。结论:INH-B与多囊卵巢综合征(PCOS)发生有关,且作为PCOS特征的肥胖又影响着INH-B的作用和水平。更多还原

【Abstract】 Objective To investigate the changes of serum inhibin B(inhibin.INH-B) levels in women with polycystic ovary syndrome(PCOS) and the relationship with body mass index(BMI).Methods Serum insulin-like growth factor-I(IGF-I),fasting insulin(In),and leptin(with RIA) inhibin B(INH-B)(with ELISA) and luteinizing hormone(LH),follicle-stimulating hormone(FSH),human prolactin(PRL),estradiol(E2) testosterone(T)(with CLIA) levels were measured in 40 patients with PCOS and 40 controls.24 of the 40 PCOS patients were of the obese group(BMI>25) and 16 were non-obese.Results Serum leptin,In,LH,T levels were significantly higher but INH-B,IGF levels were significantly lower in obese group than those in non-obese group(P<0.05).There were negetive correlations between LH and INH levels(r=-0.730,P<0.05 in obese group but nore in non-obese group serum).INH-B,IGF,LH,T levels in non-obese group were significantly higher than those in the controls(P<0.05).Conclusion Inhibin is closely related to the development of PCOS,the level of serum inhibin is lower in obese patients with PCOS.更多还原