【摘要】 环境污染物几乎都以混合物的形式存在。文章以污染物联合毒性研究的发展为主线,介绍了联合毒性定性研究方法(毒性单位TU法、加和指数AI法、混合毒性指数MTI法及相似参数λ法)和定量研究方法(以TU和λ为参数的方法和混合化合物的定量结构-活性相关QSAR法),简要概述了各方法的优缺点。发现目前已有的研究方法大都还停留在定性并逐步向定量发展的阶段,指出了其中借鉴单一化合物QSAR模型而发展起来的混合化合物定量结构———活性相关(M-QSAR)模型尚处在开始成型的"初级"阶段,但它是21世纪可持续发展的新生力量,它的发展必将推动我国环境污染化学的进一步发展,为污染物的生态风险评价提供更为可靠的科学方法和理论依据。更多还原

【Abstract】 Environmental pollutants are almost mixtures. Advances on joint toxicological effect of mixture pollutants were reviewed according to development of various stages. Methods from qualitative to quantitative study of joint toxicological effect together with disadvantages and advantages were systematically introduced,with focus on qualitative study and development of quantitative study. M-QSAR,which draws lessons from QSAR of individual chemicals,is still at primary stage, but is prospective for sustainable development in 21st century,which can not only facilitate the development of environmental pollution chemistry but provide more reliable scientific approaches and theory basis to estimate ecology risk of pollutant.更多还原