【摘要】 背景与目的探讨完整切除术后IIIA期非小细胞肺癌(Non-small cell lung cancer,NSCLC)的床预后因素。方法对1999年1月至2004年12月中山大学肿瘤防治中心收治288例手术切除的IIIA期非小细胞肺癌患者进行生存分析,生存率的计算及单因素生存分析用Kaplan-Meier法,Log-rank法检验;Cox比例风险模型进行多因素分析。结果288例手术切除的IIIA期非小细胞肺癌患者的中位生存期为770天,1年、2年、3年、4年和5年的累计生存率分别为77.1%、52.4%、34.9%、28.1%和20.2%。单因素生存分析发现年龄(<60岁vs≥60岁)、是否吸烟、手术方式、T分期、术后化疗、术后化疗疗程数、术后放疗7个临床因素与IIIA期NSCLC患者术后的预后有统计学意义,进一步利用Cox比例风险模型进行多因素分析发现术后化疗、术后放疗、T分期是影响预后的独立因素。结论术后化疗、术后放疗、T分期是影响IIIA期非小细胞肺癌预后的重要因素。更多还原

【Abstract】 Background and objective To investigate potential clinical prognostic factors in completely resected stage IIIA non-small cell lung cancer (NSCLC). Methods Proceeding survival analysis of 288 pathological Stage IIIA NSCLC patients with completely resection which in Cancer center of Sun Yat-sen University from Jan 1999 to Dec 2004.Prognostic factors were estimated using the Kaplan-Meier ang log-rank analysis. The Cox regression model evaluated the influence of factors on the survival. Results Univariate analysis identified 7 significant prognostic clinical factors including age, smoking, T stage, operative approach, postoperative chemotherapy, numbers of postoperative chemotherapy cycles, postoperative radiotherapy. In multivariate analysis, 3 independent prognostic factors entered the model: T stage, postoperative chemotherapy and postoperative radiotherapy. Conclusion T stage, postoperative chemotherapy, postoperative radiotherapy have the prognostic signi cance in postoperative stage IIIA NSCLC.更多还原