【摘要】 目的:观察辛伐他汀对阿霉素肾病大鼠的肾脏保护作用。方法:雄性SD大鼠24只随机分为正常对照组、阿霉素肾病组(模型组)和阿霉素肾病辛伐他汀治疗组(治疗组),一次性尾静脉注射阿霉素6.5mg/kg建立肾病大鼠模型。治疗组每日给予辛伐他汀(3mg/kg)灌胃,对照组和模型组每日灌等量生理盐水,分别灌胃11周,于注射阿霉素后第12周末结束实验。考马斯亮蓝法检测24h尿蛋白定量,全自动生化仪检测血清生化学指标,光镜和电镜观察肾组织病理形态学变化,统计肾小球硬化指数。结果:模型组24h尿蛋白定量、血脂、血肌酐水平及肾小球硬化指数明显高于对照组,辛伐他汀明显降低阿霉素肾病大鼠24h尿蛋白、血肌酐水平及肾小球硬化指数(P<0.01)。治疗组和模型组血脂差异无统计学意义。结论:辛伐他汀可以不依赖于其降血脂的效应,对阿霉素肾病大鼠发挥肾脏保护作用。更多还原

【Abstract】 Objective:To observe the reno-protective effect of simvastatin on adriamycin(ADR) induced nephropathy rats.Methods:Male Sprague-Dawley rats were randomly divided into control,ADR nephrosis and simvastatin-treated ADR nephrosis groups.ADR nephropathy was induced by a single tail intravenous injection of ADR(6.5 mg/kg).Simvastatin at 3 mg/kg body weight was administered once a day by gavage,the control rats and the ADR nephrosis rats received 0.9% saline once a day by gavage.Treatment was started 6 d after ADR injection and lasted 11 weeks.Twenty four hours urinary protein excretion was measured with the Coomassie brilliant blue method,serum albumin(ALB),total cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL) and creatinine(Cr) were measured with an automatic biochemical analyzer,histopathological changes were observed under light microscopy and transmission electron microscope,and glomerulosclerosis index(GSI) was also evaluated.Results:Simvastatin significantly decreased 24-h urinary protein excretion,serum Cr and GSI,and these changes occurred in the absence of lowering of serum lipids.Conclusions:Simvastatin has renoprotective effects on adriamycin induced nephropathy rats,independent of the lipids-lowering effects.更多还原