【摘要】 目的了解慢性重型乙型肝炎患者肝细胞再生衰竭的相关指标及其临床意义。方法检测慢性重型乙型肝炎患者的肝功能及相关生化指标,观察其临床转归,并比较慢性重型乙型肝炎肝衰竭患者中死亡者与存活者之间有关检查结果的差异,探寻其与肝细胞再生衰竭的关系。结果死亡组谷氨酰转肽酶(γ-GT)、血清白蛋白(ALB)随着病情加重呈进行性下降,而血清总胆红素(TB IL)进行性上升;好转组γ-GT、ALB随时间延迟趋于平行或有所回升,血清胆红素在发病第2周上升至最高,以后呈进行性下降;两组之间TB IL、γ-GT、ALB差异有统计学意义(P<0.05)。结论临床观察上述指标有助于了解慢性重型乙型肝炎患者肝细胞坏死程度及肝干细胞新生肝细胞的能力,判断肝细胞再生衰竭,有助于为人工肝支持治疗及肝移植提供理论依据。更多还原

【Abstract】 Objective To observe the biochemical index and clinical significances of hepatocytes regeneration failure in patients with chronic severe viral hepatitis B. Methods According to the prognosis,162 patients with chronic severe viral hepatitis B were divided into death group(n=45) and survival group(n=117),to detect the serum levels of TBIL,γ-GT,ALB,ALT and AST.Results The worse the prognosis of the liver disease,The less γ-GT and ALB,the more TBIL,in death groups.The better the prognosis of the liver disease,The more γ-GT and ALB,The TBIL levels were the highest in the second week,and the late it was decreased,in survival groups,compared with them showed difference(P<0.05).Conclusions To observe the clinical chronic severe viral hepatitis B data to know hepatic stem cell proliferation,understanding liver cell regeneration failure,and offering artificial liver support treatment and liver transplantation theories.更多还原