【摘要】 目的探讨单纯经肝动脉化疗栓塞(TACE)及联合肿瘤间质治疗后肝癌患者免疫功能的变化及意义。方法对照组(A组)20例肝癌患者行单纯TACE治疗,实验组(B组)20例肝癌患者行经肝动脉化疗栓塞联合经皮肝瘤内药物注射碘油化疗药物肿瘤间质治疗。术前及术后1周抽取两组患者外周血,应用流式细胞仪检测外周血T淋巴细胞亚群(CD3+T、CD4+T、CD8+T、CD4+T/CD8+T),单向扩散法检测免疫球蛋白水平变化。结果A、B组手术后1周CD3、CD4及CD4/CD8升高,两组手术前后比较有显著性差异(P<0.05);A、B两组术后比较,除CD8外亦有显著性差异(P<0.05)。A、B组术后免疫球蛋白和补体有所升高,A组手术前后无显著性差异(P>0.05);B组手术前后除C3外具有显著性差异(P<0.05),A、B两组术后比较无显著性差异(P>0.05)。结论单纯TACE治疗肝癌增强患者细胞免疫功能,对体液免疫影响较小;联合瘤内碘油化疗药物乳剂注射肿瘤间质治疗的方法可以更大程度地改善患者细胞免疫和体液免疫功能。更多还原

【Abstract】 Objective To study the changes of immune function in patients with liver cancer after transcatheter arterial chemoembolizaton(TACE) combined with interstitial therapy.Methods Forty patients with liver cancer were randomly divided into groups A and B to received TACE and TACE combined with percutaneous lipiodol and anti-cancer agent injection into the tumor.The T lymphocyte cell subsets in the peripheral blood before and one week after the operation were measured by flow cytometry,and the immunoglobulin contents determined by single radial immunodiffusion.Results CD3,CD4,and CD4/8 levels increased significantly after the operation in both groups A and B(P<0.05).The postoperative CD3 and CD4 levels,but not that of CD8,differed significantly between the two groups(P<0.05).The operations also resulted in an increase in the contents of the immunoglobulins and complements in the two groups,but the changes were not significant in group A(P>0.05);in group B,significant increases occurred in the immunoglobulin and complement levels(P<0.05) with the exception of C3.Conclusion The combination of TACE and interstitial therapy with percutaneous intratumor injections of lipiodol and anti-cancer agents may better improve the cell-mediated immunity and humoral immune function of liver cancer patients.更多还原