【摘要】 目的Meta分析左西孟旦对失代偿心衰患者B型利钠肽(BNP)水平的影响,并评价左西孟旦在左心衰治疗中的疗效。方法采用Meta分析法对收集到的相关文献进行严格的定量分析。结果左西孟旦静脉用药后24h时BNP平均降低337.66pg/ml,其95%CI为(-296.30,-379.02);48h时平均降低259.92pg/ml,其95%CI为(-195.76,-324.08);第1周平均降低123.09pg/ml,其95%CI为(-53.32,-195.86)。各时点心功能与用药前相比约分别增加了29%、22%、10%。结论左西孟旦能改善失代偿心力衰竭患者心功能,显著降低血浆BNP水平。更多还原

【Abstract】 Objective To conduct a meta-analysis of the effect of levosimendan on B-type natriuretic peptide(BNP) levels and evaluate the therapeutic effect of levosimendan on advanced heart failure.Methods A meta-analysis was performed on the selected data to analyze the effect of levosimendan on BNP levels.Results Levosimendan decreased BNP by a mean of 337.66 [95%CI(-296.30,-379.02)] pg/ml 24 h after the administration,and by 259.92 [95%CI(-195.76,-324.08)] pg/ml at 48 h,and by 123.09 [95%CI(-53.32,-195.86)] pg/ml at 1 week.Levosimendan resulted in improvements of the cardiac function by about 29%,22%,and 10% at 24 h,48 h and 1 week after the administration.Conclusion Levosimendan produces favorable effects on the cardiac functions and BNP levels.更多还原