【摘要】 目的:探讨鼻咽癌(NPC)淋巴结转移MRI表现及其与蛋白P53表达的关系.方法:收集首次放射治疗前行MRI检查且临床资料完整的NPC患者110例,用SP法检测P53蛋白的表达情况,分析淋巴结转移的MRI表现与P53蛋白的关系.结果:颈部淋巴结双侧转移率为34.0%(17/50),咽后外侧淋巴结双侧转移率为11.4%(4/34),两者之间差异有统计学意义(P<0.05).茎突前间隙受累病例中颈部淋巴结转移率为48.4%(30/62),茎突前间隙未受侵犯组颈部淋巴结转移率为52.1%(25/48),两组之间差异无统计学意义.茎突后间隙受侵犯组颈部淋巴结转移率为68.2%(30/44),茎突后间隙未受侵犯组颈部淋巴结转移率为30.3%(20/66),两组之间差异有统计学意义(P<0.01).颈深部淋巴结转移中P53蛋白阳性表达率为78.0%(39/50),咽后外侧淋巴结转移中P53蛋白阳性表达率为77.1%(27/35).结论:NPC有较高的淋巴结转移率,茎突后间隙的受累与颈部淋巴结转移有关,颈部淋巴结转移与P53蛋白的阳性表达无明显相关性.更多还原

【Abstract】 AIM:To study the relationship between MR imaging manifestations of lymph nodes metastasis of naspharyngeal carcinoma(NPC)and expression of p53 protein.METHODS:One hundred and ten patients,who had been diagnosed with NPC and whose MR imaging was performed before treatment,were enrolled in this study.The expression of p53 protein was detected by S-P immunohistochemical technique and a comparison was made between the MRI manifestations of the lymph nodes metastasis of the napharyngeal carcinoma and p53 expression.RESULTS:The bilateral metastasis rate of cervical nodes was 34.0%(17/50)and the bilateral metastasis rate of the retropharyngeal lymph nodes was 11.4%(4/34),with statistically significant difference(χ2=5.64,P=0.018).The cervical nodes metastasis rate in patients with and without prestyloid space involvement was respectively 48.4%(30/62)and 52.1%(25/48),with no statistically significant difference(χ2=0.148,P=0.701).The cervical nodes metastasis rate in patients with and without retrostyloid spaces involvement was respectively 68.2%(30/44)and 30.3%(20/66),with statistically significant difference(χ2=15.278,P=0.000).The positive-expression rate of p53 proteins was 78.0%(39/50)in patients with cervical nodes metastasis and 77.1%(27/35)in patients with retropharyngeal lymph nodes metastasis,with no statistically significant difference(χ2=0.028,P=0.868 and χ2=0.000,P=0.982).CONCLUSION:The lymph nodes metastasis rate is high in naspharyngeal carcinoma.Cervical nodes metastasis is highly correlated to the retrostyloid spaces involvement,but lymph nodes metastasis is not correlated to the expression of p53 protein.更多还原