【摘要】 目的:对伴远处转移胰腺癌患者化疗风险预测模型进行研究.方法:回顾性分析87例出现远处转移的胰腺癌患者应用5-Fu,顺铂、吉西他滨等化疗后的预后.结果:全组中位生存时间为3.8 mo;3,6,12 mo的生存率分别为58%,26%和3%.Cox累计风险比例模型分析提示:腹水、血清胆碱酯酶水平(ChE)<110 U/L和年龄≥65岁都是独立的不良预后因素.结论:伴远处转移胰腺癌患者化疗风险预测模型:相对死亡风险(RRD)=exp(腹水×1.213+ChE×1.065+年龄×0.651).更多还原

【Abstract】 AIM: To establish the predictive model of systemic chemotherapy risks in pancreatic cancer patients with distant metastasis.METHODS: Eighty-seven pancreatic cancer patients with distant metastasis treated with systemic chemotherapy using 5-fluorouracil,cisplatin or gemcitabine were analyzed retrospectively to investigate the prognostic factors.RESULTS: The overall median survival time of all the patients under study was 3.8 months,and the survival rates of 3,6 and 12 months were 58%,26% and 3% respectively.Cox proportional hazards model showed that independent poor prognostic factors were the presence of ascites,serum ChE level<110 U/L,and age≥65.CONCLUSION: The predictive model of systemic chemotherapy risks in pancreatic cancer patients with distant metastasis is: the relative risk of death(RRD)=exp(presence of ascites×1.213 + serum ChE level×1.065+age≥65×0.651).更多还原