Caffeine Markedly Enhanced Radiation-Induced Bystander Effects

【摘要】 <正> In this paper it is shown that incubation with 2 mM caffeine enhanced significantlythe MN(micronucleus)formation in both the 1 cGy α-particle irradiated and non-irradiated by-stander regions.Moreover,caffeine treatment made the non-irradiated bystander cells more sensi-tive to damage signals.Treated by c-PTIO(2-(4-carboxy-phenyl)-4,4,5,5-tetramethyl-imidazoline-l-oxyl-3-oxide),a nitric oxide(NO)scavenger,the MN frequencies were effectively inhibited,showing that nitric oxide might be very important in mediating the enhanced damage.Theseresults indicated that caffeine enhanced the low dose a-particle radiation-induced damage in ir-radiated and non-irradiated bystander regions,and therefore it is important to investigate therelationship between the radiosensitizer and radiation-induced bystander effects(RIBE).更多还原

【Abstract】 In this paper it is shown that incubation with 2 mM caffeine enhanced significantly the MN(micronucleus)formation in both the 1 cGy α-particle irradiated and non-irradiated by- stander regions.Moreover,caffeine treatment made the non-irradiated bystander cells more sensi- tive to damage signals.Treated by c-PTIO(2-(4-carboxy-phenyl)-4,4,5,5-tetramethyl-imidazoline- l-oxyl-3-oxide),a nitric oxide(NO)scavenger,the MN frequencies were effectively inhibited, showing that nitric oxide might be very important in mediating the enhanced damage.These results indicated that caffeine enhanced the low dose a-particle radiation-induced damage in ir- radiated and non-irradiated bystander regions,and therefore it is important to investigate the relationship between the radiosensitizer and radiation-induced bystander effects(RIBE).更多还原