【摘要】 [目的]观察干酪菌发酵产物对豚鼠离体回肠平滑肌的作用。[方法]采用豚鼠离体回肠平滑肌标本,观察加入干酪菌发酵产物前后肌紧张和收缩幅度的变化。给药浓度分别为ZPL 1.5×103mg/L、3.0×103mg/L、6.0×103mg/L、12.0×103mg/L、18.0×103mg/L、24.0×103mg/L。[结果]干酪菌发酵产物3.0×103mg/L、6.0×103mg/L、12.0×103mg/L豚鼠离体回肠平滑肌肌紧张分别为123%、132%、138%,组间比较差异有显著性意义(P<0.01);6.0×103mg/L、12.0×103mg/L、18.0×103mg/L豚鼠离体回肠平滑肌收缩幅度分别为171%、316%、354%,组间比较差异有显著性意义(P<0.01)。[结论]干酪菌发酵产物能提高豚鼠离体回肠平滑肌肌紧张和收缩幅度,且呈剂量-效应依赖关系。更多还原

【Abstract】 [Objective] To study the effects of zymotic fluid of polypor laetiporus(ZPL) on smooth muscular tension and contraction of isolated ileum of guinea pig.[Methods] Isolated guinea pig ileum was incubated in an organ bath,and muscle tense and contraction amplitude were observed.The dose of ZPL were 1.5×103mg/L,3.0×103mg/L,6.0×103mg/L,12.0×103mg/L,18.0×103mg/L,24.0×103mg/L.[Results] ZPL 3.0×103mg/L,6.0×103mg/L,12.0×103mg/L increased muscle tense,Which was 123%,132%,138% respectively;and ZPL(6.0×103)mg/L,(12.0×103)mg/L,(18.0×103)mg/L increased contraction amplitude,Which was 123%,132%,138% respectively.[Conclusion] ZPL could significantly augment the spontaneous contraction of pig ileum with dose dependent manner.更多还原