【摘要】 目的探讨CT引导下经皮穿刺组织间植入125I粒子治疗老年中心型肺癌的近期疗效。方法30例经细胞学或组织学确诊的老年中心型肺癌(鳞状细胞癌),随机分成A、B两组,A组为125I粒子治疗组(15例),采用经皮穿刺组织间125I粒子植入术,125I粒子放射性活度为0.8mCi/颗,据TPS计划系统确定粒子放射性总活度和布源。B组为对照组(15例),采用经支气管动脉化疗药物灌注术,灌注的化疗药物为环磷酰胺、阿霉素及卡铂。结果A组总有效率(CR+PR)86.67%,B组总有效率(CR+PR)53.33%,二者比较具显著统计学意义。A组病例治疗后新发生椎体(T12)转移1例。B组病例治疗后新发生纵隔淋巴结转移1例,脑转移1例。结论经皮穿刺组织间植入I125放射微粒子治疗老年中心型肺癌(鳞状细胞癌)近期疗效显著,优于单纯经支气管动脉化疗药物灌注术。更多还原

【Abstract】 Objective: To discuss the effect of central bronchogenic cancer by percutaneous interstitial 125I particle implanting under CT guided in elder patients. Methods: 30 elder patients with central bronchogenic cancer (squamous carcinoma) approved by pathology were divided into two groups at randomized controlled trial (RCT). Patients in group A were treated with percutaneous interstitial 125I particle implanting under CT guided. The number of 125I particle were 25～40. The radioactivity quantum were 0.8mCi per granule. The overall radioactivity quantum were 20-32 mCi. 2～6 puncture points were selected. 15 patients in group B accepted bronchial arterial infusion (BAI). Cisplatinum, Adriblastine and CTX were injected into bronchial arteries. Results: Entire response rate (CR+PR) reached 86.67% in group A and 53.33% in group B, showing significant difference (P<0.05). There was vertebra metastasis in one case after 6 months of implanting of 125I particle. Cerebra metastasis and mediastinum lymphonode metastasis were showed in plain CT scan after BAI. Conclusion: Compare to BAI, percutaneous interstitial 125I particle implanting shows higher entire response rate for elder patients with bronchogenic carcinoma.更多还原