【摘要】 在可降解AZ31B镁合金心血管支架表面成功制备了携带雷帕霉素的聚乳酸-聚三亚甲基碳酸酯(PLA-PTMC)共聚物涂层,评价了涂层的表面形貌、降解性能、血液相容性和药物释放性能。结果表明,PLA-PTMC共聚物作为载药涂层具有良好的柔韧性,表面均匀、光滑,降解周期超过1个月,血液相容性良好。涂层具有缓释雷帕霉素的功能,释药周期超过1个月,可在内膜增生期内有效抑制支架植入后再狭窄的发生,满足冠脉支架表面载药层的使用要求。更多还原

【Abstract】 The sirolimus-releasing PLA-PTMC coating was successfully prepared on the biodegradable AZ31B magnesium alloy coronary stents.The surface morphology,degradability,biocompatibility and drug release characteristic of the coating were also evaluated.The results indicated that PLA-PTMC used as the drug elution coating showed good flexibility with smooth and uniform surface,the degradation period was over one month,and the biocompatibility was excellent.The drug-loaded coating had releasing function of sirolimus and the releasing time was more than one month,which could effectively inhibit the restenosis during the period of intima hypertrophy.The sirolimus-releasing PLA-PTMC coating showed potential to be used as a new type of coronary stent coating.更多还原