【摘要】 目的探讨肝移植治疗原发性肝癌(primary hepatic carcinoma,PHC)的术后生存率及其影响因素。方法回顾性分析2000年8月以来我院89例接受肝移植且随访时间≥6个月的PHC患者的临床资料。结果89例患者肝移植术后1、2和3年生存率分别为91.2%、68.5%、59.4%;单因素分析显示,肿瘤最大直径、门静脉癌栓、肿瘤分化程度和肿瘤TNM分期是影响生存率的重要因素,Cox风险模型多因素分析显示,肿瘤最大直径、肿瘤分化程度和肿瘤TNM分期是影响生存率的独立危险因素。结论肝移植是目前治疗PHC的有效方法,肿瘤直径>5cm、肿瘤分化程度差和肿瘤TNM分期高均严重影响患者的生存率。更多还原

【Abstract】 Objective To evaluate the survival and prognostic factors of liver transplantation for primary hepatic carcinoma(PHC).Methods Clinical and follow-up data of 89 PHC patients who underwent liver transplantation in our hospital since Aug.2000 and were followed up more than 6 months were retrospectively analyzed.Results The 1-year,2-year and 3-year cumulative survival rates of the 89 patients were 91.2%,68.5% and 59.4%,respectively.Univariate analysis revealed the maximum tumor diameter,the presence of portal vein tumor thrombus,histological differentiation and TNM stage were major factors affecting the survival.Multivariate analysis using Cox proportional hazards regression model demonstrated the maximum tumor diameter,histological differentiation and TNM stage were the in-dependent risk factors affecting the survival.Conclusions Liver transplantation is an effective treatment for PHC.The tumor diameter>5 cm,poor histological differentiation and high TNM stage significantly affect the survival of PHC patients.更多还原