【摘要】 目的探讨血清β2-微球蛋白(β2-MG)对肾功能的预测价值。方法测定356例患者血清中的β2-MG、尿素(Urea)、肌酐(Cre)和尿酸(UA)等4项指标的水平,分析4项指标间的相关性及联合测定上述指标的意义。结果356例患者中,β2-MG增高组(176例患者)的血清Urea、Cre、UA的水平都显著高于β2-MG正常组(180例患者)(P<0.001)。在β2-MG增高组中,有52例患者的Urea水平显著增高,其相应的β2-MG、Cre和UA的水平都显著高于Urea正常组的对应指标(P<0.001)。Urea、Cre、UA与β2-MG之间相关系数r分别为0.661、0.785、0.508(P<0.001),Cre与β2-MG之间有很强的相关性。结论血清β2-MG水平可作为肾损害的一个重要指标,比Urea、Cre及UA的测定能较早地反映肾功能状态,联合测定β2-MG、Urea、Cre及UA4项指标对肾功能损害的准确诊断有重要临床价值。更多还原

【Abstract】 Objective To study the predictive value of renal function by serum β2-microglobulin(β2-MG).Methods Detected the levels of four indicators(β2-MG,Urea,Cre,UA) from Sera of 356 patients analyzed correlation of four indicators and significance of combined determination from the indicatros.Results Among 356 patients,the levels of Urea,Cre,UA from β2-MG Higher group(176 patients) were significantly higher than those from β2-MG normal group(180 patients)(P<0.001).Among the β2-MG Higher group,the Urea levels of 52 patients were significantly increased and their levels of β2-MG,Cre,UA were significantly higher than those from Urea normal group(P<0.001).Correlation coefficient r between β2-MG and Urea,Cre,UA were 0.661,0.785 and 0.508(P<0.001),and there was a strong correlation between β2-MG and Cre.Conclusion The Levels of Serum β2-MG can reflect the status of renal function earlier than the levels of Urea,Cre,UA and it can be an important indicator to judge kidney damage.There will be an important clinical value to diagnose kidney damage accurately through joint detectation of β2-MG,Urea,Cre and UA.更多还原