【摘要】 目的分析对比更昔洛韦和α-干扰素治疗传染性单核细胞增多症(IM)的临床疗效。方法将82例IM患儿随机分为GCV组41例和IFN-α组41例,在一般对症治疗基础上,GCV组用GCV 10mg.kg-1.d-1静脉滴注,IFN-α组用IFN-α100万u/d肌肉注射,对临床体征及相关实验室指标的变化进行观察分析。结果GCV组退热和咽峡炎好转平均时间以及平均住院时间均较IFN-α组明显缩短(P<0.05),GCV组显效率46.34%高于IFN-α组24.39%(P<0.05)。结论短期使用GCV治疗小儿IM安全有效,且其疗效较IFN-α更好,更值得临床推广使用。更多还原

【Abstract】 Objective To analyse the clinical effect of α-interferon and ganciclovir on treating infectious mononucleosis(IM).Methods Eighty-two children with IM were randomly divided into two groups and treated with α-interferon intramuscular(1 000 000u/d) and ganciclovir intravenously(10mg·kg-1·d-1) respectively,the effects of the two drugs were analysed.Results The average duration of fever,angina and hospitalization in the group with ganciclovir was shorter than that in the other one,while the excellence rate of ganciclovir group was 46.34% compelled with which of α-interferon group was 24.39%,And the differences were significant.Conclusion Ganciclovir for children with IM is effective and safe,the effect of which is better than α-interferon,and it should be widespread.更多还原