【摘要】 临床上常见的抗精神病药产生的药物副反应有锥体外系反应、药物性肝损伤、性功能障碍、闭经、粒细胞减少症、药物性皮炎、消化系统功能紊乱、体质量异常增加等。根据患者服用抗精神病药后毒副作用的临床表现,运用"有诸内必形诸外、司外揣内、取类比象、审症求因、以药测证"等中医临床认识模式,可以发现,在常规治疗过程中,抗精神病药作用于人体,根据体质和药物的不同,产生的不同副作用和毒性反应,但大致不离脾胃郁热、阳明热盛;热盛风动、津亏生风;痰湿内生、络脉瘀阻。对抗精神病药引起的药源性疾病辨证施治,在临床实践中取得了较为显著的疗效,治法以清热、泻下、补气、养阴、活血、化痰为主,其中养阴、活血具有特殊意义。更多还原

【Abstract】 In clinical, the common side effects of antipsychotic were extrapyramidal symptoms, drug-induced liver injury, sexual dysfunction, amenorrhea, neutropenia, drug-induced dermatitis, digestive disorders, abnormal increase in body weight, etc. According to patients clinical manifestations of side effects of antipsychotics and chinese medical clinic cognitive model of ‘outer appearance from inside essence’, ‘conjecturing the interior by observing the exterior’, ‘analogy by classifi cation’, ‘identifying etiology by symptoms differentiation’, ‘syndrome determination by drugs’, etc., it can be found that in conventional treatment course, different antipsychotic drugs acted on the different human body may induce different side effects and different toxic reaction, generally including stagnation of heat in spleen-stomach, excessive heat in Yangming, excessive heat generating wind, body fluid deficiency generating wind, internal retention of phlegm and dampness, obstruction of collaterals. TCM differential treatment to antipsychotic-induced disease obtained a more signifi cant effect. Clearing away heat, purgative activity, invigorating qi, nourishing yin, activating blood flow, resolving phlegm were the basic treatment methods, of which nourishing yin, activating blood flow were of particular signifi cance.更多还原