【摘要】 目的:对雷公藤生药整体固态生物转化后的分段提取物进行小鼠脏器系数、血液学和血液生化指标的比较,初步判断生物转化产物与原药材之间毒性的大小。方法:小鼠脏器重量测定、测定血液学和血液生化指标。结果:转化后的产物依据菌种的不同,对毒性的影响也有差异。曲霉菌转化产物毒性降低较为明显,而单一的根霉菌,以及酵母与毛霉菌混合(复合菌)的转化产物其毒性对不同的指标表现不一,有降低的,也有增强的。与原药相比TW-2号样品毒性与其相似,TW-1号毒性小于原药,TW-3号毒性最小。结论:转化后样品与未转化的对照品(原药)在小鼠脏器系数,血液学、血液生化指标上发生了一定的变化,提示转化产物的毒性有所降低,所含的活性物质基础有所改变。更多还原

【Abstract】 Objective:To study the toxicity of the fermentated products from the well known medicinal plant Tripterygium wilfordii(TW).Methods:The organs weights,changes of blood samples as well as blood biochemistry standards of the mice were measured.Results:The toxicity was different according to the species of fungi used in fermentation.Compared with the original materials,the sample TW-3(using Aspergillus spp.in fermentation) showed the lowest toxcity,the sample TW-1(using Rhizopus spp.in fermentation) showed the lower toxcity than the original materials and the sample TW-2(combined fungi species) showed the similar toxcity as the original materials.Conclusion:The toxicity of the bioconversion product decreased and its chemical constituents may change.更多还原