【摘要】 目的:观察中药制剂清脂复肝颗粒对大鼠高脂血症和酒精性肝损伤混合型脂肪肝模型的影响。方法:以高脂饲料喂养作为脂肪肝形成的基础,加上酒精对肝脏的损伤制作大鼠慢性(混合型)脂肪肝动物模型,采用清脂复肝颗粒做治疗性给药试验,对脂质、肝脏疾病常用血清酶等以及肝脏病理组织学检查观察药物的疗效和安全性。结果:清脂复肝颗粒可降低血脂水平,促进肝内脂质代谢,改善酒精毒性所致肝损伤,减轻肝脏脂肪变性的程度。结论:清脂复肝颗粒对大鼠高脂血症和酒精性肝损伤混合脂肪肝模型具有改善和治疗作用。更多还原

【Abstract】 Objective:To observe influence of qingzhifugan pellet on mixed-type animal model of fatty liver with chronic hyperlipemia and alcoholized hepatic damage. Methods:The mixed-type animal model of fatty liver was established by administering with high lipids and alcohol feeds. Therapeutic experiments were conducted with a self-made new drug the qingzhifugan pellet. The efficacy of the tested drug was evaluated comprehensively by such measures as sero-level of lipids and ferments,as well as the histological pathology of liver. Results:It was shown that the tested drug can decrease the sero-level of lipids,promote the metabolism of lipids in liver,recover the alcoholized hepatic damage,and relieve the liver fat denaturation. Conclusion:It suggested that the tested drug possessed certain effect for treating or improving chronic hyperlipemia and alcoholized hepatic damage in the animal model.更多还原