【摘要】 对255例经131I治疗的Graves病(GD)患者治疗前未用抗甲状腺药物(anti-thyroid drugs,ATD)治疗、用ATD的咪唑类和硫氧嘧啶类治疗的三组病例观察,评价ATD和ATD不同药物对131I治疗GD的影响。比较使用甲巯咪唑(methimazole,MMI)的GD患者(B组)停药一周,使用丙基硫氧嘧啶(proylthiouracil,PTU)的GD患者(C组)停药10天,实施131I治疗后,与未用ATD治疗的GD患者(A组)用131I治疗后的疗效差异。结果显示,A组131I一次治愈率为94.3%,二次治疗率为5.7%,未发生第三次治疗;B组131I一次治愈率81.7%,二次治疗率为18.3%,未发生第三次治疗;C组131I一次治愈率为57.6%,二次治疗率为39.0%,发生第三次治疗为3.4%。A组与B组、A组与C组、B组与C组的第一次治愈率和发生第二次、第三次的治疗率有极显著性差异(P<0.001)。结论:131I治疗前经ATD干预后或干预中的GD患者131I的治愈率显著降低。更多还原

【Abstract】 To analyze the effects of different Anti-thyroid drugs(ATD) upon the 131I treatment of Graves’ Disease(GD),255 GD cases,which were either treated without ATD(group A),with MMI(group B) or with PTU(group C) respectively before their 131I treatment were observed.They were treated with 131I10 days after group C had stopped taking Proylthiouracil(PTU),and 7 days after group B had stopped taking Methimazole(MMI).Group A was treated with 131I only.The results showed that once curing rate of 131I in group A was 94.3%,while twice curing rate was 5.7%,and third treatment was not performed.Once curing rate of group B was 81.7% and twice was 18.3%,and third treatment was not performed.Once curing rate of group C was 57.6%,and twice was 39.0% and third was 3.4%.Significant differences between the groups appeared among the curing rates(P<0.001).Conclusion: The 131I curing rate is dramatically decreased after the interference with ATD in patients with GD.更多还原