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心血管疾病患儿血浆内皮素水平的初步研究
Clinical Value of Plasma Endothelin Levels in Children with Cardiovascular Diseases
【摘要】 探讨心血管疾病患儿血浆内皮素(ET-1)的应用价值,选择77例心力衰竭、肥胖症、高脂血症、脂肪肝和高血压病(五组)患儿和21名健康儿童为对照组,采用RIA测定血浆ET-1水平,经t检验处理。结果表明,五组的血浆ET-1水平分别为112.8±34.1ng/L、57.8±19.1ng/L、64.5±25.3ng/L、74.9±28.4ng/L和60.7±21.6ng/L,与对照组43.5±10.2ng/L比较均有显著性差异(P<0.01或P<0.05)。提示血浆ET-1水平升高与心血管相关疾病密切相关,对诊断患儿病情有一定的参考价值。
【Abstract】 To explore the clinical value of plasma endothelin(ET-1) levels in children with cardiovascular diseases,77 children with heart failure,obesity,hyperlipemia,fatty liver and hypertension were divided into 5 experimental groups and 21 health children with same age and gender as control group.The plasma levels of ET-1 in these children were tested by RIA.The results showed that plasma levels of ET-1 in 5 experimental groups were 112.8±34.1ng/L,57.8±19.1ng/L,64.5±25.3ng/L,74.9±28.4ng/L and 60.7±21.6ng/L,respectively.The ET-1 levels in 5 groups were significantly higher than that in control group(P<0.01).The results indicate the higher plasma ET-1 levels in children are related with cardiovascular diseases,and it is useful in the diagnosis of children cardiovascular diseases.
【Key words】 Heart failure; Obesity; Hyperlipemia; Fatty liver; Hypertension; Endothelin; Children;
- 【文献出处】 标记免疫分析与临床 ,Labeled Immunoassays and Clinical Medicine , 编辑部邮箱 ,2009年05期
- 【分类号】R725.4;R817.4
- 【被引频次】4
- 【下载频次】46