【摘要】 将mRNA靶定到神经细胞树突中,对区域化蛋白质合成和神经功能的发挥起重要作用。神经细胞mRNA存在于包含不同种类调控mRNA定位、稳定和翻译组分的颗粒中。该颗粒由驱动蛋白1(kinesin 1)沿微管运输。定向运输产生的mRNA不对称分布是突触可塑性、学习和记忆所必需的。更多还原

【Abstract】 The targeting of mRNAs to neuronal dendrites plays an important role for neuronal local protein synthesis and function.Neuronal mRNAs in granules such as RNP containing diverse components of controlling mRNA localization,stability,and translation,are transported by kinesin 1 along microtubules.An asymmetric distribution of mRNAs caused by the transport is essential to synaptic plasticity,learning,and memory.更多还原