【摘要】 目的探讨冠心病(CHD)病人血清中血管内皮细胞生长因子(VEGF)水平与幽门螺杆菌(Hp)感染情况的变化及其临床意义。方法将经临床确诊的CHD病人60例分为稳定型心绞痛(SAP)组、不稳定型心绞痛(UAP)组、急性心肌梗死(AMI)组、陈旧性心肌梗死(OMI)组,每组各15例,以20例健康查体者作为对照组。应用ELISA法分别检测其血清VEGF水平和Hp-IgG表达。结果CHD病人血清VEGF水平与Hp-IgG阳性率显著高于对照组(t=8.030,P<0.01;2χ=4.310,P<0.05),SAP、UAP、AMI与OMI组病人血清VEGF水平之间两两比较,差异有显著性(F=65.01,q=3.11~18.11,P<0.05、0.01)。Hp-IgG阳性者血清VEGF水平显著高于阴性者(t=9.208,P<0.01)。结论CHD病人血清VEGF与Hp-IgG水平显著升高,且在一定程度上反映了病情的变化,联合检测VEGF和Hp-IgG对预测冠心病的病变程度、判断预后有一定的价值。更多还原

【Abstract】 Objective To explore the changes and clinical significance of serum levels of vascular endothelial growth factor(VEGF) and Helicobacter pylory-IgG(Hp-IgG) in patients with coronary heart disease(CHD). Methods Sixty CHD patients confirmed clinically were evenly divided into stable angina pectoris(SAP) group,unstable angina pectoris(UAP) group,acute myocardium infarction(AMI) group and old myocardium infarction(OMI) group.Twenty healthy people served as normal controls.Serum VEGF and Hp-IgG were determined by enzyme-linked immunosorbent assay(ELISA). Results The serum level of VEGF and the positive rate of Hp-IgG in the CHD patients were significantly higher than those in the controls(t=8.030,P<0.01;χ2=4.310,P<0.05).The serum level of VEGF was significantly different among each other of SAP,UAP,AMI and OMI groups(F=65.01;q=3.11-18.11;P<0.05,0.01).The serum level of VEGF in Hp-IgG positive individuals was higher than that in Hp-IgG negative individuals(t=9.208,P<0.01). Conclusion The serum levels of VEGF and Hp-IgG were elevated in patients with CHD,which surely reflects the changes of the disease.A combination examination of serum Hp-IgG and VEGF is of a certain value in prediction of the disease and its prognosis.更多还原