【摘要】 背景与目的:以往研究表明恶性度越高的淋巴瘤对2-氟-18-氟-2-脱氧-D-葡萄糖(18F-FDG)摄取也越高,本研究对不同病理亚型淋巴瘤患者全身浸润病灶对FDG的摄取情况进行分析,并探讨淋巴瘤FDG的摄取与亚型之间的关系。方法:回顾性分析102例初诊淋巴瘤患者的影像与临床资料,在PET/CT图像上对每一个单独浸润病灶测量其最大标准化摄取值(standardized uptake value,SUV),再与纵隔血池最大SUV值相比,得出每例患者全身平均肿瘤/纵隔血池比值(tumor SUVmax/mediastinal SUVmax,T/MB),进而得出各病理亚型淋巴瘤全部患者T/MB平均值。然后分析霍奇金淋巴瘤(Hodgkin’s lymphoma,HL)与非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL),HL与惰性NHL、侵袭性NHL,NHL中B细胞性NHL与NK/T细胞性NHL、弥漫大B细胞淋巴瘤不同临床分期之间差异有无显著性。同时对4例全身大部分病灶无明显FDG摄取的淋巴瘤患者及对照组高摄取FDG的淋巴瘤患者活检淋巴结Ki67指标进行分析。结果:HL与NHLT/MB值分别为4.50±1.54、5.21±2.86(P=0.154);侵袭性NHL要远高于惰性NHL、HL(P<0.001);B细胞性NHL与NK/T细胞性NHL的T/MB值分别为5.29±3.00与4.91±2.30(P=0.57);弥漫大B细胞淋巴瘤不同临床分期之间T/MB值差异无统计学意义。4例无明显FDG摄取的淋巴瘤患者,活检淋巴结Ki67阳性率低于阳性对照组。结论:淋巴瘤全身病灶摄取FDG的高低,与淋巴瘤侵袭性有关,与细胞学起源及临床分期无关。本研究中4例淋巴瘤患者全身大部分病灶无明显FDG摄取可能与Ki67阳性率低下有关。更多还原

【Abstract】 Background and Objective : Malignant lymphoma has high 2-fluorine-18-fluoro-2-deoxy-D-glucose (18F-FDG) uptake. This study was to analyze 18F-FDG uptake of lymphoma lesions of various histological subtypes. Methods: FDG PET / CT images of 102 naive lymphoma patients were analyzed. The maximal standardized uptake value (SUVmax) of every single lesion and the SUVmax of mediastinal blood pool were measured and used to calculate the mean T / MB value (tumor SUVmax / mediastinal SUVmax) of every patient. The mean T / MB value of the patients with the same subtype of lymphoma was calculated. The differences in T / MB value between Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) patients, between HL and indolent NHL, invasive NHL patients, between B-cell NHL and NK / T-cell NHL patients, and between diffuse large B-cell lymphoma (DLBCL) patients of different stages were analyzed. The expression of Ki-67 in lymph nodes from four patients with relative low T / MB value was detected. Results: The T / MB values were 4.50±1.54 in HL patients and 5.21±2.86 in NHL patients (P=0.154). The T / MB value was significantly higher in invasive NHL patients than in HL and indolent NHL patients (P<0.001). The T / MB values were 5.29±3.00 in B-cell NHL patients and 4.91±2.30 in NK / T-cell NHL patients (P=0.57). There was also no significant difference between DLBCL patients of different stages. The positive rate of Ki-67 was lower in the four patients with relative low T / MB value than in positive control group. Conclusions: 18F-FDG uptake of lymphoma lesions is related to lymphoma invasion, but not related to cell origin and clinical stage. The low 18F-FDG uptake in four patients may be related to low expression of Ki-67.更多还原