【摘要】 目的研究茯苓总三萜对急、慢性炎症的抑制作用。方法采用二甲苯诱导的小鼠耳肿胀、冰醋酸诱导的小鼠腹腔毛细血管通透性实验、角叉菜胶诱导的大鼠足爪肿胀、棉球诱导的大鼠肉芽肿模型,观察茯苓总三萜的抗炎作用。结果茯苓总三萜(50、150、450 mg.kg-1)灌胃(ig)给药对二甲苯诱导的小鼠耳肿胀和冰醋酸引起的腹腔毛细血管渗出有明显的抑制作用;能明显减轻角叉菜胶诱导的大鼠足爪肿胀、棉球诱导的大鼠肉芽肿。结论茯苓总三萜具有良好的抗炎作用。更多还原

【Abstract】 Aim To study the anti-inflammatory effect of triterpene acids from poria cocos(TAPC).Methods Various inflammatory models,including the swelling of ear induced by dimethyl benzene in mice,the permeability increase of blood capillary by acetic acid in mice,hind paw edema induced by carrageenin in rat and granuloma induced by cotton pellet implantation in rat were used to explore the anti-inflammation of TAPC.Results TAPC(50,150,450 mg·kg-1,ig) could significantly inhibit the ear edema and celiac capillary permeation in mice,markedly inhibit paw edema induced by carrageenin and granuloma induced by cotton pellet in rats.Conclusion TAPC has a remarkable anti-inflammatory effect.更多还原