【摘要】 目的分析比较坦索罗辛联合排石冲剂和单纯应用排石冲剂在输尿管下段结石辅助排石中的疗效。方法160例输尿管下段结石患者随机分2组,每组80例。结石直径0.4~1.0 cm。组1给予坦索罗辛0.4 mg,1次/天,并联合服用排石冲剂1包(12 g)冲服,2次/天;组2仅服用排石冲剂1包(12 g)冲服,2次/天。每例患者治疗观察期不超过2周。结果2周内结石排出者组1为63例(78.8%),组2为50例(62.5%),两组比较排石率差异有统计学意义(P<0.05)。平均排石时间组1为4.5 d,组2为8d,两组比较差异有统计学意义(P<0.05)。2周内组2有5例患者因发生肾绞痛而需镇痛药治疗,组1中无肾绞痛发生。2周内两组均未出现明显副作用,无因不能耐受而退出者。结论坦索罗辛和排石冲剂的联合应用可促进输尿管下段和膀胱壁间段结石排出,且和单纯应用排石冲剂相比能缩短排石时间,减少排石过程的疼痛和镇痛药使用。更多还原

【Abstract】 Aim To compare the efficacy of tamsulosin combined lithagogue diluent versus lithagogue diluent for the adjunctive expulsive therapy in patients with lower ureteral stones.Methods A total of 160 patients with stones(0.4~1.0 cm in diameter) located in the lower ureter(juxtavesical or intramural tract) were randomly divided into 2 groups(80 cases in each group).Group 1 received tamsulosin combined lithagogue diluent(tamsulosin,0.4mg,once daily;lithagogue diluent,12g,twice daily),while group 2 received lithagogue diluent(12g,twice daily).All patients were observed for 2 weeks.Results During the 2 weeks,expulsion of stones was observed in 63 cases(78.8%) of group 1,and 50(62.5%) of group 2.The difference in expulsion rates between groups was statistically significant(P<0.05).The mean expulsion time of group 1 and 2 was 4.5 and 8 d,respectively,with significant difference between groups(P<0.05).In group 1 and 2,renal colic recurred within 2 weeks and analgesics were used in 0 and 5 cases,respectively.All the patients tolerated the expulsive therapy and no one withdrew from treatment.No obvious side effect occurred.Conclusions It demonstrates that tamsulosin combined lithagogue diluent are safe and effective of adjunctive expulsive treatment of lower ureteral stones.更多还原