【摘要】 目的探讨妊娠合并梅毒的筛查、治疗及妊娠结局,降低不良妊娠结局的发生率。方法对53例经血清学筛查并确诊为妊娠合并梅毒的临床资料进行回顾性分析,根据妊娠期是否行全疗程抗梅毒治疗,将其分组,比较两组孕妇的妊娠结局。结果53例中Ⅱ期梅毒3例(5.66%),余均为潜伏期梅毒(94.34%)。治疗组引产3例,妊娠至围产期的孕妇26例,其中无死胎、畸胎及新生儿死亡。先天梅毒儿1例(3.45%),不良妊娠结局发生率37.93%,而未治疗组的不良妊娠发生率为100%。结论妊娠合并梅毒的临床分期以潜伏期梅毒为主;梅毒是导致不良妊娠结局的重要因素,但妊娠期应及早进行规范的抗梅毒治疗,能很好控制死胎、畸胎和新生儿死亡的发生,以改善不良妊娠结局。更多还原

【Abstract】 Objective To investigate obstetric treatment and pregnancy outcome of syphilis infection during pregnancy.Methods In a retrospective study, we evaluated 53 pregnant women (19-36 years) diagnosed with syphilis by serological assays. The 53 cases were divided into treated group and untreated group according to whether they accepted a full course anti-syphilis therapy or not. The pregnancy outcome were observed and compared between the two groups.Results There were 29 cases (54.72%) screened and final diagnosed during the first or second trimester of pregnancy, 24 cases (45.28%) were not diagnosed until peripartum, and 3 cases of secondary syphilis (5.66%), 50 cases of latent syphilis(94.34%) among the 53 cases. Three patients requested to give her induced abortion and 26 cases carried pregnancy to prenatal stage in the treated group. Among the 26 cases, there were no cases of fetal intrauterine death, fetal anomaly, neonatal death, and 1 cases of congenital syphilis; while 3, 4, 2, and 7 in the untreated group respectively. Pregnancy outcome were obviously improved in treated group.Conclusion The clinical stage of syphilis is mainly latent phase during pregnancy. Syphilis in pregnancy is a serious harmful complication to the fetus, but fetal intrauterine death, fetal anomaly and neonatal death can be well controlled through regular and earlier treatment against syphilis during pregnancy. It is also the key for improving the pregnancy outcome.更多还原