【摘要】 目的:观察胰岛素治疗初诊重度2-型糖尿病(T2DM)疗效。方法:初诊重度T2DM50例,随机分为胰岛素治疗组(n=26)和口服磺脲类治疗组(n=24)两组,观察治疗前和治疗6个月后各组的FBG、P2hBG、HbA1c、空腹C肽、餐后2hC肽。结果:治疗6个月后胰岛素治疗组的FBG、P2hBG、HbA1c、空腹C肽、餐后2hC肽变化明显优于口服磺脲类治疗组(P<0.05),轻度低血糖发生率两组大体相当,重度低血糖发生率胰岛素治疗组明显低于口服磺脲类治疗组。结论:胰岛素是控制疗初诊重度2-型糖尿病血糖的有效方法。更多还原

【Abstract】 Objective: Clinical investigation on therapy effectiveness of insulin in firstly diagnosed severe type 2 diabetes mellitus (T2DM) patients. Methods: 50 firstly diagnosed severe T2DM patients were randomly divided into two groups, insulin aspart 30 group (n=26) and oral sulfonylureas drugs group (n=24). Pre- and post-treatment of FBG、P2hBG、HbA11c、fasting peptide C、postprandial peptide C of each group were measured after 6 months treatment. Results: Levels of FBG、P2hBG、HbA1c、fasting peptide C、postprandial peptide C in the insulin group are significantly ameliorated than the sulfonylureas group (P<0.05).Mild hypoglycemia incidence is similar between two groups, but severe hypoglycemia incidence in insulin group is significantly lower than in sulfonylureas group. Conclusion: Insulin aspart 30 can effectively reduce blood glucose in firstly diagnosed severe T2DM patients.更多还原