【摘要】 目的:观察康莱特胶丸联合肝动脉化学栓塞(transcatheter arterial chemoembolization,TACE)治疗中晚期原发性肝癌的疗效。方法:将65例患者随机分为2组,综合组(康莱特胶丸+TACE)32例,对照组(单纯TACE)33例,比较2组近期疗效、血清甲胎蛋白(alpha fetoprotein,AFP)、外周血T淋巴细胞亚群(T lymphocyte subsets,T-LS)、生活质量(quality of life,QOL)、肿瘤进展时间(time to progession,TTP)和不良反应。结果:综合组客观有效率、血清AFP与对照组相仿(P>0.05),T-LS(CD3+、CD4+、CD4+/CD8+细胞比值)、QOL、TTP、肝脏不良反应等方面明显优于对照组,差异有统计学意义(P<0.05)。结论:康莱特胶丸联合TACE是治疗失去手术治疗机会的原发性肝癌的有效方法之一。更多还原

【Abstract】 Objective: To observe the clinical effects of kanglaite capsules combined with transcatheter arterial chemoembolization(TACE) on patients with advanced unresectable hepatocellular carcinoma(HCC).Methods: Sixty-five cases were divided into 2 groups at random.In treatment group,32 patients received kanglaite capsules after TACE and 33 patients in control group were treated with TACE singly.The objective response rate(RR),serum alpha fetoprotein(AFP),peripheral blood T lymphocyte subsets(T-LS),quality of life(QOL),time to progression(TTP),and adverse reaction were observed.Results: The objective response rate and serum alpha fetoprotein levels had no significant difference between the two groups(P>0.05).Treatment group was superior to control group in the quality of life(QOL),the time to progression(TTP),peripheral blood T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+ ratio),and frequency of adverse reactions in liver.The difference was significant(P<0.05).Conclusion: Kanglaite capsules combined with TACE was an effective method for primary HCC patients who have lost the surgical chance.更多还原