【摘要】 目的:了解活血通络法对激素性股骨头坏死(SANFH)家兔模型的血液流变学影响,以研究其作用机制。方法:将40只家兔随机分为空白对照组,SANFH模型组及活血通络方高、中、低3个剂量组,每组8只。用糖皮质激素造成SANFH模型,活血通络方高、中、低3个剂量组分别灌服活血通络汤混悬液10.0、5.0、2.5ml.kg-1,模型组和空白对照组均灌服10ml.kg-1蒸馏水。分别于治疗4、6、8周进行血液流变学相关数据变化的观测和比较。结果:全血高切、中切、低切黏度及血浆黏度比较,模型组明显高于空白对照组(P<0.01)。活血通络方各剂量组均低于模型组(P<0.01)。且随着剂量的增加,血液流变学相关数据明显降低,组间比较差异有统计学意义(P<0.05)。结论:血液流变学异常是SANFH的主要发病机制之一,活血通络方可显著改善SANFH的血液流变学状态。更多还原

【Abstract】 Objective:To approach the influence of HUOXUETONGLUOTANG(HXTLT,) on hemorheology of steroid-induced necrosis of femoral head(SANFH) in rabbit’s models,and it’s mechanism of action.Methods:40 cases of rabbits were randomly divided into five groups,group A(blank group,distilled water was drenched at 10 ml.kg-1),group B(model group,drug was the same to group A),group C(high dose group,suspl was given at 10.0 ml.kg-1),group D(middle dose group,at 5.0 ml.kg-1) and group E(low dose group,at 2.5 ml.kg-1),8 cases in each group.They were made into models of SANFH by glucocorticosteroid.After 4 weeks,6 weeks and 8 weeks of teatment,correlated datas of hemorheology were determioned and compared.Results:On comparion of whole high blood viscosity,middle viscosity and low viscosity,plasma viscosity,datas of group B were super to those of group A(P < 0.01),there had difference on groups of C,D and E with group A(P < 0.05).Datas in groups of C,D and E were obviously lower than those in group B(P < 0.01).With the increasing of dose,related datas of hemorheology degraded obviously.There had statistical significance on discrepancy of group comparison.Conclusion:Abnormal hemorheology was one of main pathogenesy on SANFH,and HXTLT could notably improve the state of hemorheology in SANFH.更多还原