【摘要】 以中国37个不同民族9个常染色体STR基因座的群体遗传研究数据资料为例,探讨群体遗传学研究中常染色体STR基因座等位基因检出数量与样本量之间的关系,即样本量对等位基因检出数量的影响。结果显示在一定范围之内,样本量的大小与所观测到的不同基因座等位基因检出数量之间存在正相关关系。当超过一定范围时,样本量的继续增加不再明显影响等位基因的检出数量。杂合度较低的位点随样本量的变化波动较大,杂合度较高的位点随样本量的变化波动较小。更多还原

【Abstract】 Objective:Few studies was done to examine the Sample collection and sampling strategy in population genetic studies,though sample can greatly influence the analysis and interpretation of the data obtained.Here we examined effects of sample size on the observed number of allele of 9 STR loci(D3S1358,vWA,FGA,TH01,TPOX,CSF1PO,D13S317,D5S818,D7S820) of 37 populations.The results show: that the quantity of alleles and the quantity of samples was not obviously corresponding,while the populations with few samples had more allelomorphic genes detected.And there was no influence on the quantity of the allele observed when the quantity of the samples reached to a certain extent.H was up to a stable level when the quantity of sample was 50.Those who had low H(such as TPOX) changed obviously with the quantity of samples,while those had high genetic parameters(such as FGA) changed a little with the quantity of samples.更多还原