【摘要】 目的苦参碱注射液对婴儿巨细胞病毒性肝炎患者肿瘤坏死因子-α(TNF-α)的影响。方法将42例婴儿巨细胞病毒(CMV)肝炎患儿随机分为苦参碱治疗组(n=22)与更昔洛韦对照组(n=20)。两组均予以常规保肝降酶治疗为基础。苦参碱治疗组用苦参碱注射液20~25mg/d静脉滴注,每日1次,连用14天;间隔7~10天后20~25mg/kg.d静脉滴注,每日1次,连用5天,共2~3个疗程。更昔洛韦对照组用更昔洛韦5mg/kg.d静脉滴注,每日2次,连用14天;间隔7~10天后5mg/kg.d静脉滴注,每日1次,连用5天,共2~3个疗程。观察两组TNF-α水平变化。结果治疗前、后苦参碱注射液对血TNF-α、TBIL、ALT的变化。(P<0.01)。结论苦参碱注射液治疗婴儿巨细胞病毒性肝炎疗效确切,可能与抑制TNF-α释放有关。更多还原

【Abstract】 Objective:To observe the treatment of infants’ Cytomegalovirus hepatitis with Matrlne injection.Methods:Fourty-two cases of CMV hepatitis were randomly divided into tow groups: the treated group(n =22) and the control group(n = 20).The treated group with Matrlne(25 mg/ d) once daily for 14 days.After 7～10 day with Matrlne(25 mg/ d) once daily for 5 days.Then repeat 2～3 time.The control group with Ganciclovir 5md/kg·d twice daily for 14days.After 7～10 day with Ganciclovir 5md/kg·d twice daily for 5 days,then repeat 2～3 time.Results:There were significant differences in IBIL and TBA between the two groups after two weeks(P<0.05).There were very significant differences in time of initial jaundice disappearance and complete disappearance after two weeks(P<0.01).Conclusion:As enitial Ademetionine,Transmetil could supplement absenced endogenesis Ademetionine,efficiencly decrease intestines-liver ciculation,protect scathing liver cell,accelerate jautice fadeaway.更多还原