【摘要】 目的:制备包茎松凝胶并建立质量控制方法。方法:以倍他米松和红霉素为主药,卡波姆-940为主要基质制备凝胶;采用紫外可见分光光度法测定其中主药含量。结果:所得凝胶符合凝胶剂质量要求,质量控制方法准确可靠.倍他米松检测浓度在6.15～20.49μg·ml^-1范围内线性关系良好（r=0.999 4）,平均回收率为98.34%,RSD=0.80%;红霉素检测浓度在10.09～60.55μg·ml^-1范围内线性关系良好（r=0.999 1）,平均回收率为97.79%,RSD=1.79%。结论:本制备工艺简单可行;质控方法可控制该制剂质量。更多还原

【Abstract】 Objective:To prepare Baojingsong hydrogel and establish its quality control method.Method:Erythomycin and beta- methasone were used as principal drugs,carboner-940 was used as key base material,and the Baojingsong hydrogel was preparaed; The contents of the principal drugs were determined by vis-UV speetrophotometry.Result:The Baojingsong hydrogel was suitable with quality requirement,and the quality control method was reliable,accurate.The detection concentration of betamethasone was linear within the ranges of 6.15-20.49μg·ml^-1（r=0.999 4）,and the average recovery rate was 98.34% with RSD 0.80%.The detec- tion concentration of erythromycin was linear within the ranges of 10.09-60.55μg·ml^-1（r=0.999 1）,and the average recovery rate was 97.79% with RSD 1.79%.Conclusion:The preparing procedure was convenient and feasible.The quality control method could control the quality of Baojingsong hydrogel.更多还原