【摘要】 目的:研究人参皂苷Rh2与化疗药环磷酰胺（CTX）联合应用,在小鼠肉瘤180（S180）的实验性治疗中呈现出何种交互作用,根据其交互作用,提示及建议在将来的临床治疗中如何合理联用。方法:以小鼠S180为模型,采用正交设计方法进行实验,确定Rh2和CTX联合应用于小鼠S180的实验性治疗中,两者之间是否存在交互作用、以及交互作用的性质,并通过析因设计方法进行进一步的验证。结果:正交实验结果显示,Rh2与CTX联用时存在交互作用,表现为拮抗作用;进一步的析因实验验证,一定剂量的Rh2(0.5 mg·kg^-1)与CTX(8 mg·kg^-1)联用时,存在拮抗作用。结论:Rh2与CTX联合应用时,减弱了CTX的抗肿瘤作用,两药不宜同时应用于化疗中。更多还原

【Abstract】 Objective:To investigates the cross effect between ginsenoside Rh2 and therapeutic drug cyclophosphamide (CTX) on the sarcoma 180 (S180) bearing in mice treated by ginsenoside Rh2 combining with CTX.Method:The antitumor effect of ginsenoside Rh2 combining CTX on the S180 bearing in mice was evaluated by tumor weight.The cross effect between ginsenoside Rh2 and CTX on growth of S180 was identified by using orthogonal design experiment and the result was further proven by factorial design experiment. Result:The cross effect was found in experimental antitumor treatment,and the cross effect exhibited antagonism.Conclusion:Gin- senoside Rh2 is able to reduce the experimental chemotherapeutical effect of CTX when the combination of both.更多还原